In this essay, the main focus is on the question whether the Food & Agri industry should leverage technology in general, and CRISPR-Cas9 in particular, to drive the big change needed; the change of humankind itself. It is argued that technology has sparked an entirely new evolutionary phase for human kind. An analysis is performed that comes to the conclusion that use of technologies involves inconvenient questions and that risk, uncertainty and ignorance are very different things. Society itself must seek ways to address these questions and the desirability and possible implications of the answers to these questions because it is difficult for governments to establish the required regulatory oversight that would go beyond what is acceptable to the same society.